Functional analysis of conserved non-coding regions around the short stature hox gene (shox) in whole zebrafish embryos.

Functional analysis of conserved non-coding regions around the short stature hox gene (shox) in whole zebrafish embryos.

Mutations in the SHOX gene are responsible for Leri-Weill Dyschondrosteosis, a disorder characterised by mesomelic limb shortening. Recent investigations into regulatory elements surrounding SHOX have shown that deletions of conserved non-coding elements (CNEs) downstream of the SHOX gene produce a...

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Bibliographic Details
Main Authors: Emma J Kenyon, Gayle K McEwen, Heather Callaway, Greg Elgar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3123344?pdf=render

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