The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation

The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation

Anaphase-promoting complex or cyclosome (APC/C) is a multisubunit ubiquitin ligase E3 that targets cell-cycle regulators. Cdc20 is required for full activation of APC/C in M phase, and mediates substrate recognition. In vertebrates, Emi2/Erp1/FBXO43 inhibits APC/C-Cdc20, and functions as a cytostati...

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Bibliographic Details
Main Authors: Shisako Shoji, Yutaka Muto, Mariko Ikeda, Fahu He, Kengo Tsuda, Noboru Ohsawa, Ryogo Akasaka, Takaho Terada, Motoaki Wakiyama, Mikako Shirouzu, Shigeyuki Yokoyama
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
APC/C
Emi2
ZBR domain
Cdc20
Ubiquitin ligase activity
UBE2C
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000667

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http://www.sciencedirect.com/science/article/pii/S2211546314000667

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