Internal Ribosome Entry Site Dramatically Reduces Transgene Expression in Hematopoietic Cells in a Position-Dependent Manner
Bicistronic transgene expression mediated by internal ribosome entry site (IRES) elements has been widely used. It co-expresses heterologous transgene products from a message RNA driven by a single promoter. Hematologic gene delivery is a promising treatment for both inherited and acquired diseases....
Main Authors: | Qingyun Zheng, Xueyan Zhang, Hua Yang, Jinyan Xie, Yilin Xie, Jinzhong Chen, Chenghui Yu, Chen Zhong |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
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Series: | Viruses |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4915/11/10/920 |
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