Development of chiral metal amides as highly reactive catalysts for asymmetric [3 + 2] cycloadditions

Development of chiral metal amides as highly reactive catalysts for asymmetric [3 + 2] cycloadditions

Highly efficient catalytic asymmetric [3 + 2] cycloadditions using a chiral copper amide are reported. Compared with the chiral CuOTf/Et3N system, the CuHMDS system showed higher reactivity, and the desired reactions proceeded in high yields and high selectivities with catalyst loadings as low as 0....

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Bibliographic Details
Main Authors: Yasuhiro Yamashita, Susumu Yoshimoto, Mark J. Dutton, Shū Kobayashi
Format: Article
Language:English
Published: Beilstein-Institut 2016-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
[3 + 2] cycloaddition
asymmetric reaction
catalytic reaction
low catalyst loading
metal amide
Online Access:https://doi.org/10.3762/bjoc.12.140

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