Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function

Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function

Super-enhancer are usually defined by high levels of chromatin modification and associate with cell-specific gene expression. Here, the authors define hyperacetylated chromatin domains (HCDs) by using histone hyperacetylation peak breadth information and show that HCDs associated more closely with c...

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Main Authors: Sierra Fox, Jacquelyn A. Myers, Christina Davidson, Michael Getman, Paul D. Kingsley, Nicholas Frankiewicz, Michael Bulger
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18303-0
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spelling doaj-ee98d3c56057456481faaea3dd0b0a5f2021-09-12T11:48:46ZengNature Publishing GroupNature Communications2041-17232020-09-0111111410.1038/s41467-020-18303-0Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer functionSierra Fox0Jacquelyn A. Myers1Christina Davidson2Michael Getman3Paul D. Kingsley4Nicholas Frankiewicz5Michael Bulger6Department of Biochemistry and Biophysics, University of Rochester Medical CenterCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical CenterCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical CenterCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical CenterCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical CenterCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical CenterCenter for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical CenterSuper-enhancer are usually defined by high levels of chromatin modification and associate with cell-specific gene expression. Here, the authors define hyperacetylated chromatin domains (HCDs) by using histone hyperacetylation peak breadth information and show that HCDs associated more closely with cell identity than super-enhancers.https://doi.org/10.1038/s41467-020-18303-0
collection DOAJ
language English
format Article
sources DOAJ
author Sierra Fox
Jacquelyn A. Myers
Christina Davidson
Michael Getman
Paul D. Kingsley
Nicholas Frankiewicz
Michael Bulger
spellingShingle Sierra Fox
Jacquelyn A. Myers
Christina Davidson
Michael Getman
Paul D. Kingsley
Nicholas Frankiewicz
Michael Bulger
Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
Nature Communications
author_facet Sierra Fox
Jacquelyn A. Myers
Christina Davidson
Michael Getman
Paul D. Kingsley
Nicholas Frankiewicz
Michael Bulger
author_sort Sierra Fox
title Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_short Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_full Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_fullStr Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_full_unstemmed Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_sort hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-09-01
description Super-enhancer are usually defined by high levels of chromatin modification and associate with cell-specific gene expression. Here, the authors define hyperacetylated chromatin domains (HCDs) by using histone hyperacetylation peak breadth information and show that HCDs associated more closely with cell identity than super-enhancers.
url https://doi.org/10.1038/s41467-020-18303-0
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AT jacquelynamyers hyperacetylatedchromatindomainsmarkcelltypespecificgenesandsuggestdistinctmodesofenhancerfunction
AT christinadavidson hyperacetylatedchromatindomainsmarkcelltypespecificgenesandsuggestdistinctmodesofenhancerfunction
AT michaelgetman hyperacetylatedchromatindomainsmarkcelltypespecificgenesandsuggestdistinctmodesofenhancerfunction
AT pauldkingsley hyperacetylatedchromatindomainsmarkcelltypespecificgenesandsuggestdistinctmodesofenhancerfunction
AT nicholasfrankiewicz hyperacetylatedchromatindomainsmarkcelltypespecificgenesandsuggestdistinctmodesofenhancerfunction
AT michaelbulger hyperacetylatedchromatindomainsmarkcelltypespecificgenesandsuggestdistinctmodesofenhancerfunction
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