Aberrant Hypermethylation of Aldehyde Dehydrogenase 2 Promoter Upstream Sequence in Rats with Experimental Myocardial Infarction

Aberrant Hypermethylation of Aldehyde Dehydrogenase 2 Promoter Upstream Sequence in Rats with Experimental Myocardial Infarction

Background. Aldehyde dehydrogenase 2 (ALDH2) plays a crucial role in myocardial protection against ischemia. Downregulation of ALDH2 was evidenced after myocardial infarction and the underlying mechanism is not fully understood. DNA methylation can regulate gene transcription in epigenetic level. We...

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Main Authors: Peng Wang, Cheng Shen, Lei Diao, Zhiyin Yang, Fan Fan, Cong Wang, Xiangwei Liu, Xiaolei Sun, Zhen Dong, Hong Zhu, Xin Ma, Quan Cao, Xiaona Zhao, Duan Ma, Yunzeng Zou, Kai Hu, Aijun Sun, Junbo Ge
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/503692

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http://dx.doi.org/10.1155/2015/503692

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