A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly.

A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly.

Integrase (IN) is an important therapeutic target in the search for anti-Human Immunodeficiency Virus (HIV) inhibitors. This enzyme is composed of three domains and is hard to crystallize in its full form. First structural results on IN were obtained on the catalytic core domain (CCD) of the avian R...

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Bibliographic Details
Main Authors: Allison Ballandras, Karen Moreau, Xavier Robert, Marie-Pierre Confort, Romain Merceron, Richard Haser, Corinne Ronfort, Patrice Gouet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3153463?pdf=render

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http://europepmc.org/articles/PMC3153463?pdf=render

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