EGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cells.

EGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cells.

Members of the EGFR/ErbB family of tyrosine kinases are found to be highly expressed and deregulated in many cancers, including head and neck squamous cell carcinoma (HNSCC). The ErbB family, including EGFR, has been demonstrated to play key roles in metastasis, tumorigenesis, cell proliferation, an...

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Bibliographic Details
Main Authors: Eric L Abhold, Alan Kiang, Elham Rahimy, Selena Z Kuo, Jessica Wang-Rodriguez, Jay Patrick Lopez, Katherine J Blair, Michael Andrew Yu, Martin Haas, Kevin T Brumund, Xabier Altuna, Andrew Patel, Robert A Weisman, Weg M Ongkeko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3288103?pdf=render

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