Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.

Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.

Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. Here, we showed that arctigenin inhibited the action of nuclear factor of activated T-cel...

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Bibliographic Details
Main Authors: Teruhito Yamashita, Shunsuke Uehara, Nobuyuki Udagawa, Feng Li, Shigetoshi Kadota, Hiroyasu Esumi, Yasuhiro Kobayashi, Naoyuki Takahashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3895012?pdf=render

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http://europepmc.org/articles/PMC3895012?pdf=render

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