Risperidone Reverses the Downregulation of BDNF in Hippocampal Neurons and MK801-Induced Cognitive Impairment in Rats

Risperidone Reverses the Downregulation of BDNF in Hippocampal Neurons and MK801-Induced Cognitive Impairment in Rats

MK-801, also known as dizocilpine, is a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist that induces schizophrenia-like symptoms. Our previous study showed that brain-derived neurotrophic factor (BDNF) signaling was upregulated in cultured hippocampal astrocytes in response to MK...

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Bibliographic Details
Main Authors: Wenjuan Yu, Min Zhu, Hongwei Fang, Jie Zhou, Le Ye, Wenyu Bian, Yuan Wang, Hui Zhu, Jie Xiao, Hao Zhu, Huafang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
MK-801
schizophrenia
risperidone
BDNF
cognitive function
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00163/full

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