Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi. However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition of T. cruzi cytochrome CYP51, the target of azoles, does not deliver sterile c...

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Bibliographic Details
Main Authors: Marianne Rocha-Hasler, Gabriel Melo de Oliveira, Aline Nefertiti da Gama, Ludmila Ferreira de Almeida Fiuza, Anna Frieda Fesser, Monica Cal, Romina Rocchetti, Raiza Brandão Peres, Xue Li Guan, Marcel Kaiser, Maria de Nazaré Correia Soeiro, Pascal Mäser
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chagas disease
tomatidine hydrochloride
drug combination
T. cruzi
lipid biosynthesis inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.617917/full

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