| Summary: | <h4>Introduction</h4>People with disabilities face socioeconomic disadvantages and they have limited access to sexual and reproductive health information. They are highly vulnerable to sexual abuse which places them at increased risk of HIV and STI infection. At present, however, little is known about the knowledge, attitude and practice of sexually transmitted diseases including HIV/AIDS and other STIs in Ethiopia. This study aimed to identify which individual factors best predict knowledge, attitudes, and practices in relation to HIV/AIDS and other STIs among people with disabilities in North-shewa zone, Ethiopia.<h4>Methods</h4>A cross-sectional study was conducted from June to October 2019. A total of 397 respondents were interviewed using a structured and pre-tested questionnaire. A systematic sampling technique was employed to select the respondents. Logistic regression was performed to analyze the data. A significant association was declared at a p-value of less than 0.05.<h4>Results</h4>Nearly half of the study participants were knowledgeable in relation to HIV/AIDS (47.3%) and STIs (46.9%). Sixty-two percent of respondents had good attitude towards evidence of HIV/AIDS while sixty-nine percent of participants had good attitude towards helpful facts of STIs. Twenty-three percent of study participants had been ever tested for HIV infections. Being married (AOR = 2.23; 95% CI = 1.92, 10.72) was associated with having good knowledge of STI. Males were 1.6 times more knowledgeable about HIV/AIDS than females (AOR = 1.60; 95% CI = 1.21, 9.12).<h4>Conclusions</h4>In this study, knowledge, attitudes, and practices of people with disabilities in relation to HIV/AIDS and other STIs were relatively low. This is clear evidence that HIV programs need to ensure that people with disabilities can access basic knowledge about HIV/AIDS and STIs.
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