Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation

Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation

Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.

Bibliographic Details
Main Authors: Dirk Benzinger, Mustafa Khammash
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05882-2
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spelling doaj-ee3b2292e31c4f589980cf5e69d193702021-05-11T09:21:48ZengNature Publishing GroupNature Communications2041-17232018-08-019111010.1038/s41467-018-05882-2Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulationDirk Benzinger0Mustafa Khammash1Department of Biosystems Science and Engineering (D-BSSE), ETH–ZürichDepartment of Biosystems Science and Engineering (D-BSSE), ETH–ZürichNatural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.https://doi.org/10.1038/s41467-018-05882-2
collection DOAJ
language English
format Article
sources DOAJ
author Dirk Benzinger
Mustafa Khammash
spellingShingle Dirk Benzinger
Mustafa Khammash
Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
Nature Communications
author_facet Dirk Benzinger
Mustafa Khammash
author_sort Dirk Benzinger
title Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_short Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_full Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_fullStr Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_full_unstemmed Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_sort pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.
url https://doi.org/10.1038/s41467-018-05882-2
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AT mustafakhammash pulsatileinputsachievetunableattenuationofgeneexpressionvariabilityandgradedmultigeneregulation
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