GHB receptors - a new trend in psychopharmacology?
Introduction: Gamma-hydroxybutyric acid (GHB) is commonly known as a recreation drug or the so-called “date rape drug”. It is also used in medicine to treat narcolepsy and alcohol addiction. GHB has an affinity for two types of receptors: GABAB and the relatively recently discovered GHB receptors. G...
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Sciendo
2018-12-01
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| Series: | Current Problems of Psychiatry |
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| Online Access: | https://doi.org/10.2478/cpp-2018-0023 |
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doaj-ee3a7fa4b0cf42b2aa9c40255357943d2021-09-06T19:22:07ZdeuSciendoCurrent Problems of Psychiatry2353-86272018-12-0119428529810.2478/cpp-2018-0023cpp-2018-0023GHB receptors - a new trend in psychopharmacology?Siembida Jakub0Karakuła Kaja1Student Research Group at the I Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of LublinStudent Research Group at the I Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of LublinIntroduction: Gamma-hydroxybutyric acid (GHB) is commonly known as a recreation drug or the so-called “date rape drug”. It is also used in medicine to treat narcolepsy and alcohol addiction. GHB has an affinity for two types of receptors: GABAB and the relatively recently discovered GHB receptors. GHB receptors were first cloned in 2003 in mice and then in 2007 in humans. So far, evidence has been presented for their impact on dopaminergic transmission, which may imply that they play a role in the pathogenesis of diseases such as schizophrenia. At the same time, it has been demonstrated that benzamide antipsychotic drugs have an affinity for GHB receptors, which is why it is postulated that some of the effects of these drugs may result precisely from this affinity.https://doi.org/10.2478/cpp-2018-0023ghbghb receptorsulpirideamisulpridebenzamides |
| collection |
DOAJ |
| language |
deu |
| format |
Article |
| sources |
DOAJ |
| author |
Siembida Jakub Karakuła Kaja |
| spellingShingle |
Siembida Jakub Karakuła Kaja GHB receptors - a new trend in psychopharmacology? Current Problems of Psychiatry ghb ghb receptor sulpiride amisulpride benzamides |
| author_facet |
Siembida Jakub Karakuła Kaja |
| author_sort |
Siembida Jakub |
| title |
GHB receptors - a new trend in psychopharmacology? |
| title_short |
GHB receptors - a new trend in psychopharmacology? |
| title_full |
GHB receptors - a new trend in psychopharmacology? |
| title_fullStr |
GHB receptors - a new trend in psychopharmacology? |
| title_full_unstemmed |
GHB receptors - a new trend in psychopharmacology? |
| title_sort |
ghb receptors - a new trend in psychopharmacology? |
| publisher |
Sciendo |
| series |
Current Problems of Psychiatry |
| issn |
2353-8627 |
| publishDate |
2018-12-01 |
| description |
Introduction: Gamma-hydroxybutyric acid (GHB) is commonly known as a recreation drug or the so-called “date rape drug”. It is also used in medicine to treat narcolepsy and alcohol addiction. GHB has an affinity for two types of receptors: GABAB and the relatively recently discovered GHB receptors. GHB receptors were first cloned in 2003 in mice and then in 2007 in humans. So far, evidence has been presented for their impact on dopaminergic transmission, which may imply that they play a role in the pathogenesis of diseases such as schizophrenia. At the same time, it has been demonstrated that benzamide antipsychotic drugs have an affinity for GHB receptors, which is why it is postulated that some of the effects of these drugs may result precisely from this affinity. |
| topic |
ghb ghb receptor sulpiride amisulpride benzamides |
| url |
https://doi.org/10.2478/cpp-2018-0023 |
| work_keys_str_mv |
AT siembidajakub ghbreceptorsanewtrendinpsychopharmacology AT karakułakaja ghbreceptorsanewtrendinpsychopharmacology |
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1717772743446888448 |