Chromatid recommensuration after segmental duplication

• Main Author: Jabbour Mark N
• Format: Article
• Language: English
• Published: BMC 2009-01-01
• Series: Theoretical Biology and Medical Modelling
• Online Access: http://www.tbiomed.com/content/6/1/1

<p>Abstract</p> <p>Background</p> <p>Midsegment duplication (dup) of chromatid arms may be symmetric or asymmetric. It can be argued that every dup should yield a discommensured RC with (a) loss of at least one duplicated unit to the template counterpart and; (b) deletion of all sections of the replicating chromatid arm that are distal to both the gap left by the duplicating process and the segment closest to the centromere.</p> <p>Hypothesis</p> <p>Mechanisms capable of recommensuring the stack of chromatids after topological shifts of duplicated units (dups) are discussed. The mechanics might fail in few cases, which are discussed in terms of statistics and scalability.</p> <p>Conclusion</p> <p>The dynamics of the highly non-linear processes discussed here may be relevant to duplications of smaller (epsilon) subunits such as telomeric units within malignant genomes.</p>