REST-governed gene expression profiling in a neuronal cell model reveals novel direct and indirect processes of repression and up-regulation.

REST-governed gene expression profiling in a neuronal cell model reveals novel direct and indirect processes of repression and up-regulation.

The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes, mostly based on indirect criteria, and demon...

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Bibliographic Details
Main Authors: Jose M. eGarcia-Manteiga, Silvia eBonfiglio, Lucrezia eFolladori, Maria L. eMalosio, Dejan eLazarevic, Elia eStupka, Davide eCittaro, Jacopo eMeldolesi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
RNA-Seq
PC12 clones
different REST levels
differential gene expression.
cooperative transcription factors
mechanisms of repression and up-regulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00438/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00438/full

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