Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction

Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction

Nine indole derivatives (9a-i) were tested as potential inhibitors of the Keap1–Nrf2 interaction. This class of compounds increases the intracellular levels of the transcription factor Nrf2 and the consequent expression of enzymes encoded by genes containing the antioxidant response element (ARE). I...

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Bibliographic Details
Main Authors: Barbara Cosimelli, Giovanni Greco, Sonia Laneri, Ettore Novellino, Antonia Sacchi, Giorgio Amendola, Sandro Cosconati, Roberta Bortolozzi, Giampietro Viola
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
indole derivatives
keap1–nrf2 interaction
keap1–nrf2-are system
oxidative stress
antioxidant response element
Online Access:http://dx.doi.org/10.1080/14756366.2019.1623209

Internet

http://dx.doi.org/10.1080/14756366.2019.1623209

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