Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis

Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis

Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a stro...

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Main Authors: Kelvin H. M. Kwok, Karen S. L. Lam
Format: Article
Language:English
Published: Academya Publishing Co. 2017-05-01
Series:Endocrinology and Metabolism
Subjects:
Fibroblast growth factor 21
Atherosclerosis
Dyslipidemia
Online Access:https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-145.pdf
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spelling doaj-ede7eeed0ac74c329dcacb6e1120c8662020-11-24T22:49:49ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782017-05-0132214515110.3803/EnM.2017.32.2.145Fibroblast Growth Factor 21 Mimetics for Treating AtherosclerosisKelvin H. M. Kwok0Karen S. L. Lam1State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong.State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong.Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a strong correlation between circulating FGF21 levels and the incidence and severity of atherosclerosis. Animal studies have demonstrated a beneficial role of FGF21 in protecting against aberrant lipid profile, while recent development in FGF21 mimetics has provided further insight into the lipid-lowering effects of FGF21 signaling. The present review summarizes the physiological roles of FGF21, and discusses major breakthroughs and limitations of FGF21 mimetic-based therapeutic strategies for treating atherosclerosis.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-145.pdfFibroblast growth factor 21AtherosclerosisDyslipidemia
collection DOAJ
language English
format Article
sources DOAJ
author Kelvin H. M. Kwok
Karen S. L. Lam
spellingShingle Kelvin H. M. Kwok
Karen S. L. Lam
Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
Endocrinology and Metabolism
Fibroblast growth factor 21
Atherosclerosis
Dyslipidemia
author_facet Kelvin H. M. Kwok
Karen S. L. Lam
author_sort Kelvin H. M. Kwok
title Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
title_short Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
title_full Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
title_fullStr Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
title_full_unstemmed Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
title_sort fibroblast growth factor 21 mimetics for treating atherosclerosis
publisher Academya Publishing Co.
series Endocrinology and Metabolism
issn 2093-596X
2093-5978
publishDate 2017-05-01
description Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a strong correlation between circulating FGF21 levels and the incidence and severity of atherosclerosis. Animal studies have demonstrated a beneficial role of FGF21 in protecting against aberrant lipid profile, while recent development in FGF21 mimetics has provided further insight into the lipid-lowering effects of FGF21 signaling. The present review summarizes the physiological roles of FGF21, and discusses major breakthroughs and limitations of FGF21 mimetic-based therapeutic strategies for treating atherosclerosis.
topic Fibroblast growth factor 21
Atherosclerosis
Dyslipidemia
url https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-145.pdf
work_keys_str_mv AT kelvinhmkwok fibroblastgrowthfactor21mimeticsfortreatingatherosclerosis
AT karensllam fibroblastgrowthfactor21mimeticsfortreatingatherosclerosis
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