Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors

Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors

Summary: Cell lineage reprogramming via transgene overexpression of key master regulatory transcription factors has been well documented. However, the poor efficiency and lack of fidelity of this approach is problematic. Synthetic transcription factors (sTFs)—built from the repurposed CRISPR/Cas9 sy...

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Bibliographic Details
Main Authors: Mantas Matjusaitis, Laura J. Wagstaff, Andrea Martella, Bart Baranowski, Carla Blin, Sabine Gogolok, Anna Williams, Steven M. Pollard
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119303716

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