The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby mai...

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Bibliographic Details
Main Authors: Adam Albanese, Leonard A. Daly, Daniela Mennerich, Thomas Kietzmann, Violaine Sée
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
HIF-1α
HIF-2α
posttranslational modifications
phosphorylation
cysteine phosphorylation
Online Access:https://www.mdpi.com/1422-0067/22/1/268

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