The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby mai...

Full description

Bibliographic Details
Main Authors: Adam Albanese, Leonard A. Daly, Daniela Mennerich, Thomas Kietzmann, Violaine Sée
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
HIF-1α
HIF-2α
posttranslational modifications
phosphorylation
cysteine phosphorylation
Online Access:https://www.mdpi.com/1422-0067/22/1/268
id doaj-edd1a4a7fe994a578861aa1bddfc6678
record_format Article
spelling doaj-edd1a4a7fe994a578861aa1bddfc66782020-12-30T00:05:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012226826810.3390/ijms22010268The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and ActivityAdam Albanese0Leonard A. Daly1Daniela Mennerich2Thomas Kietzmann3Violaine Sée4Department of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L697ZB Liverpool, UKDepartment of Biochemistry and System Biology; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L697ZB Liverpool, UKFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, FI-90014 Oulu, FinlandFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, FI-90014 Oulu, FinlandDepartment of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L697ZB Liverpool, UKThe hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-α subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution, and their effects on HIF-dependent signalling are discussed in this review.https://www.mdpi.com/1422-0067/22/1/268hypoxiaHIF-1αHIF-2αposttranslational modificationsphosphorylationcysteine phosphorylation
collection DOAJ
language English
format Article
sources DOAJ
author Adam Albanese
Leonard A. Daly
Daniela Mennerich
Thomas Kietzmann
Violaine Sée
spellingShingle Adam Albanese
Leonard A. Daly
Daniela Mennerich
Thomas Kietzmann
Violaine Sée
The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
International Journal of Molecular Sciences
hypoxia
HIF-1α
HIF-2α
posttranslational modifications
phosphorylation
cysteine phosphorylation
author_facet Adam Albanese
Leonard A. Daly
Daniela Mennerich
Thomas Kietzmann
Violaine Sée
author_sort Adam Albanese
title The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
title_short The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
title_full The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
title_fullStr The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
title_full_unstemmed The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
title_sort role of hypoxia-inducible factor post-translational modifications in regulating its localisation, stability, and activity
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-12-01
description The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-α subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution, and their effects on HIF-dependent signalling are discussed in this review.
topic hypoxia
HIF-1α
HIF-2α
posttranslational modifications
phosphorylation
cysteine phosphorylation
url https://www.mdpi.com/1422-0067/22/1/268
work_keys_str_mv AT adamalbanese theroleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT leonardadaly theroleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT danielamennerich theroleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT thomaskietzmann theroleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT violainesee theroleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT adamalbanese roleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT leonardadaly roleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT danielamennerich roleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT thomaskietzmann roleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
AT violainesee roleofhypoxiainduciblefactorposttranslationalmodificationsinregulatingitslocalisationstabilityandactivity
_version_ 1724367274240901120

Similar Items