Highly Conserved <i>C</i>-Terminal Region of Indian Hedgehog <i>N</i>-Fragment Contributes to Its Auto-Processing and Multimer Formation

Highly Conserved <i>C</i>-Terminal Region of Indian Hedgehog <i>N</i>-Fragment Contributes to Its Auto-Processing and Multimer Formation

Hedgehog (HH) is a highly conserved secretory signalling protein family mainly involved in embryonic development, homeostasis, and tumorigenesis. HH is generally synthesised as a precursor, which subsequently undergoes autoproteolytic cleavage to generate an amino-terminal fragment (HH-N), mediating...

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Bibliographic Details
Main Authors: Xiaoqing Wang, Hao Liu, Yanfang Liu, Gefei Han, Yushu Wang, Haifeng Chen, Lin He, Gang Ma
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomolecules
Subjects:
Indian Hedgehog
<i>C</i>-terminal region
autoproteolytic cleavage
protein stability
multimer formation
Online Access:https://www.mdpi.com/2218-273X/11/6/792

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