Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation

Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation

Abstract Background The combination of sodium bisulfite treatment with highly-parallel sequencing is a common method for quantifying DNA methylation across the genome. The power to detect between-group differences in DNA methylation using bisulfite-sequencing approaches is influenced by both experim...

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Bibliographic Details
Main Authors: Dorothea Seiler Vellame, Isabel Castanho, Aisha Dahir, Jonathan Mill, Eilis Hannon
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Genomics
Subjects:
DNA methylation
Bisulfite sequencing
RRBS
Epigenetics
Power
Read depth
Online Access:https://doi.org/10.1186/s12864-021-07721-z

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