Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development

Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development

Transcription factors organize gene expression profiles by regulating promoter activity. However, the role of transcription factors after transcription initiation is poorly understood. Here, we show that the homeoprotein Nkx2-5 and the 5’-3’ exonuclease Xrn2 are involved in the regulation of alterna...

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Bibliographic Details
Main Authors: Keisuke Nimura, Masamichi Yamamoto, Makiko Takeichi, Kotaro Saga, Katsuyoshi Takaoka, Norihiko Kawamura, Hirohisa Nitta, Hiromichi Nagano, Saki Ishino, Tatsuya Tanaka, Robert J Schwartz, Hiroyuki Aburatani, Yasufumi Kaneda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
transcription factors
gene expression
development
Online Access:https://elifesciences.org/articles/16030

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