Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Abstract Background In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delaye...

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Bibliographic Details
Main Authors: Lucia Janickova, Karin Farah Rechberger, Lucas Wey, Beat Schwaller
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Autism
Subjects:
Parvalbumin
Calcium-binding protein
Mitochondria
Calcium homeostasis
Pvalb neurons
Autism spectrum disorder
Online Access:http://link.springer.com/article/10.1186/s13229-020-00323-8

Internet

http://link.springer.com/article/10.1186/s13229-020-00323-8

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