Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication

Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication

Carried out was comparative evaluation of the alterations of IL-1α content in the blood serum and the level of the medium mass molecules under the conditions of treating with the Yersinia pestis lipopolysaccharide (LPS) in increasing doses (from LD25 up to 2LD50). Y. pestis LPS was shown to induce I...

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Bibliographic Details
Main Authors: G. A. Afanasieva, N. P. Chesnokova, N. B. Zakharova
Format: Article
Language:Russian
Published: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2010-02-01
Series:Проблемы особо опасных инфекций
Subjects:
<i>y. pestis</i>
endotoxin
interleukin-1α
Online Access:https://journal.microbe.ru/jour/article/view/515
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spelling doaj-edb8b67a852146ae95571b1c49b55de32021-07-22T07:51:32ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2010-02-0101(103)757610.21055/0370-1069-2010-1(103)-75-76499Patterns of the Alterations of IL-1α Blood Level in Experimental Plague IntoxicationG. A. Afanasieva0N. P. Chesnokova1N. B. Zakharova2Saratov State Medical UniversitySaratov State Medical UniversitySaratov State Medical UniversityCarried out was comparative evaluation of the alterations of IL-1α content in the blood serum and the level of the medium mass molecules under the conditions of treating with the Yersinia pestis lipopolysaccharide (LPS) in increasing doses (from LD25 up to 2LD50). Y. pestis LPS was shown to induce IL-1α generation by its cell-producers with subsequent realization of this cytokine local and systematic polymodal effects. While plague intoxication induced by Y. pestis LPS increasing doses administration progressed, IL-1α content remained stably high, even in endotoxin-caused shock.https://journal.microbe.ru/jour/article/view/515<i>y. pestis</i>endotoxininterleukin-1α
collection DOAJ
language Russian
format Article
sources DOAJ
author G. A. Afanasieva
N. P. Chesnokova
N. B. Zakharova
spellingShingle G. A. Afanasieva
N. P. Chesnokova
N. B. Zakharova
Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication
Проблемы особо опасных инфекций
<i>y. pestis</i>
endotoxin
interleukin-1α
author_facet G. A. Afanasieva
N. P. Chesnokova
N. B. Zakharova
author_sort G. A. Afanasieva
title Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication
title_short Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication
title_full Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication
title_fullStr Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication
title_full_unstemmed Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication
title_sort patterns of the alterations of il-1α blood level in experimental plague intoxication
publisher Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
series Проблемы особо опасных инфекций
issn 0370-1069
2658-719X
publishDate 2010-02-01
description Carried out was comparative evaluation of the alterations of IL-1α content in the blood serum and the level of the medium mass molecules under the conditions of treating with the Yersinia pestis lipopolysaccharide (LPS) in increasing doses (from LD25 up to 2LD50). Y. pestis LPS was shown to induce IL-1α generation by its cell-producers with subsequent realization of this cytokine local and systematic polymodal effects. While plague intoxication induced by Y. pestis LPS increasing doses administration progressed, IL-1α content remained stably high, even in endotoxin-caused shock.
topic <i>y. pestis</i>
endotoxin
interleukin-1α
url https://journal.microbe.ru/jour/article/view/515
work_keys_str_mv AT gaafanasieva patternsofthealterationsofil1abloodlevelinexperimentalplagueintoxication
AT npchesnokova patternsofthealterationsofil1abloodlevelinexperimentalplagueintoxication
AT nbzakharova patternsofthealterationsofil1abloodlevelinexperimentalplagueintoxication
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