The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

The motor symptoms of Parkinson's disease (PD) are due to the progressive loss of dopamine (DA) neurons in substantia nigra pars compacta (SNc). Nothing is known to slow the progression of the disease, making the identification of potential neuroprotective agents of great clinical importance. P...

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Bibliographic Details
Main Authors: E. Ilijic, J.N. Guzman, D.J. Surmeier
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Neurobiology of Disease
Subjects:
Isradipine
6-OHDA
Substantia nigra
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001240

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