T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors

T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors

Abstract Background Cancer treatments have substantially improved childhood cancer survival but are accompanied by long-term complications, notably chronic inflammatory diseases. We hypothesize that cancer treatments could lead to long-term epigenetic changes in immune cells, resulting in increased...

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Bibliographic Details
Main Authors: Sara Daniel, Vibe Nylander, Lars R. Ingerslev, Ling Zhong, Odile Fabre, Briana Clifford, Karen Johnston, Richard J. Cohn, Romain Barres, David Simar
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Clinical Epigenetics
Subjects:
Epigenetic aging
DNA methylation
inflammation
cancer survivors
T cell
Online Access:http://link.springer.com/article/10.1186/s13148-018-0561-5

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