Modulating the Properties of Fe(III) Macrocyclic MRI Contrast Agents by Appending Sulfonate or Hydroxyl Groups

Modulating the Properties of Fe(III) Macrocyclic MRI Contrast Agents by Appending Sulfonate or Hydroxyl Groups

Complexes of Fe(III) that contain a triazacyclononane (TACN) macrocycle, two pendant hydroxyl groups, and a third ancillary pendant show promise as MRI contrast agents. The ancillary group plays an important role in tuning the solution relaxivity of the Fe(III) complex and leads to large changes in...

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Bibliographic Details
Main Authors: Didar Asik, Rachel Smolinski, Samira M. Abozeid, Travis B. Mitchell, Steven G. Turowski, Joseph A. Spernyak, Janet R. Morrow
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
Fe(III) complexes
T<sub>1</sub> contrast agents
MRI
macrocyclic ligands
TACN
sulfonate group
Online Access:https://www.mdpi.com/1420-3049/25/10/2291

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