Reactive oxygen species-sensitive thioketal-linked mesoporous silica nanoparticles as drug carrier for effective antibacterial activity

• Main Authors: Jinsong Li, Zhiyu Ding, Yuezhan Li, Jinglei Miao, Weiguo Wang, Keshav Nundlall, Shijie Chen
• Format: Article
• Language: English
• Published: Elsevier 2020-10-01
• Series: Materials & Design
• Subjects: Mesoporous silica nanoparticles (MSNs); ROS-sensitive; Controlled release; Antibacterial activity
• Online Access: http://www.sciencedirect.com/science/article/pii/S0264127520305566

Mesoporous silica nanoparticles (MSNs) carrying gatekeepers that are stimuli-responsive are widely investigated for the controlled delivery of drug at target sites. In this study, thioketal (TK) functionalized methoxy poly(ethylene glycol) (mPEG-TK) as ROS-responsive gatekeeper is used to modify MSNs and leads to a reactive oxygen species (ROS)-responsive delivery for antibacterial drug. Vancomycin (Van) was taken as the antibacterial drug and then physically encapsulated into the surface amino functionalized MSNs (N-MSNs). Subsequently, mPEG-TK was surface immobilized. Van loaded N-MSNs with surface modification of mPEG-TK (Van-mPEG-TK-MSNs) presented approximately 21% release of Van in a physiological environment in 36 h. With H2O2 increasing in the medium, the release rate of Van from Van-mPEG-TK-MSNs was significantly up-regulated following gatekeepers' disintegration. When Van-mPEG-TK-MSNs was applied in vivo, the infected site was fully cleared after 14 days and the tissue was free of infection. On the whole, the mentioned results suggested that Van-mPEG-TK-MSNs could act as a potential antimicrobial. This study can broaden MSNs' applications and advance the development of novel antibacterial agents.