A meta-analytic assessment of a Thyroglobulin marker for marbling in beef cattle

• Main Authors: Mengersen Kerrie L, Burrell Daniel L, Moser Gerhard, Wood Ian A, Hetzel D Jay S
• Format: Article
• Language: deu
• Published: BMC 2006-09-01
• Series: Genetics Selection Evolution
• Subjects: Bayesian hierarchical model; meta-analysis; association studies; TG5 marker; beef marbling
• Online Access: http://www.gsejournal.org/content/38/5/479

<p>Abstract</p> <p>A meta-analysis was undertaken reporting on the association between a polymorphism in the Thyroglobulin gene (<it>TG5</it>) and marbling in beef cattle. A Bayesian hierarchical model was adopted, with alternative representations assessed through sensitivity analysis. Based on the overall posterior means and posterior probabilities, there is substantial support for an additive association between the <it>TG5 </it>marker and marbling. The marker effect was also assessed across various breed groups, with each group displaying a high probability of positive association between the T allele and marbling. The WinBUGS program code used to simulate the model is included as an Appendix available online at <url>http://www.edpsciences.org/gse</url>.</p>