Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model

Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder and the most common cause of dementia. Various pathogenic mechanisms have been proposed to contribute to disease progression, and recent research provided evidence linking dysregulated circadian rhythms/sleep and energy metabolism...

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Bibliographic Details
Main Authors: Eunju Kim, Kazunari Nohara, Marvin Wirianto, Gabriel Escobedo, Ji Ye Lim, Rodrigo Morales, Seung-Hee Yoo, Zheng Chen
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomolecules
Subjects:
Alzheimer’s disease
female APP/PS1 mice
Nobiletin (NOB)
circadian rhythms
sleep
energy metabolism
Online Access:https://www.mdpi.com/2218-273X/11/7/1004

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