A RAT MODEL OF ALZHEIMER´S DISEASE BASED ON ABETA42 AND PRO-OXIDATIVE SUBSTANCES EXHIBITS COGNITIVE DEFICIT AND ALTERATIONS IN GLUTAMATERGIC AND CHOLINERGIC NEUROTRANSMITTER SYSTEMS

A RAT MODEL OF ALZHEIMER´S DISEASE BASED ON ABETA42 AND PRO-OXIDATIVE SUBSTANCES EXHIBITS COGNITIVE DEFICIT AND ALTERATIONS IN GLUTAMATERGIC AND CHOLINERGIC NEUROTRANSMITTER SYSTEMS

Alzheimer´s disease (AD) is one of the most serious human, medical, and socioeconomic burdens. Here we tested the hypothesis that a rat model of Alzheimer´s disease (Samaritan; Taconic Pharmaceuticals, USA) based on the application of amyloid beta42 and the pro-oxidative substances ferrous sulfate h...

Full description

Bibliographic Details
Main Authors: Tomáš ePetrásek, Martina eSkurlova, Kristyna eMaleninska, Iveta eVojtechova, Zdena eKristofikova, Hana eMatuskova, Jana eSirova, Karel eVales, Daniela eRipova, Ales eStuchlik
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Cognition
Hippocampus
Neurochemistry
Alzheimer´s disease
learning and memory
animal model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00083/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00083/full

Similar Items