The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Objective: Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the development of insulin resistance. However, the therape...

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Bibliographic Details
Main Authors: Suryaprakash Raichur, Bodo Brunner, Maximilian Bielohuby, Gitte Hansen, Anja Pfenninger, Bing Wang, Jens C. Bruning, Philip Just Larsen, Norbert Tennagels
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818308056

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