Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline

Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline

Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use. We revisited the hypothesis that minocycline acts through direct inhibition of calcium-induced mitochondrial permeability transition (mPT) resulting i...

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Bibliographic Details
Main Authors: Roland Månsson, Magnus J. Hansson, Saori Morota, Hiroyuki Uchino, Christine T. Ekdahl, Eskil Elmér
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Amyotrophic lateral sclerosis
Huntington’s disease
Parkinson’s disease
Motor neuron disease
Spinal cord injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002348

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http://www.sciencedirect.com/science/article/pii/S0969996106002348

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