Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 int...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17156-x |
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doaj-ed627a1b0d98493cb43197c2fade35f02021-07-11T11:44:08ZengNature Publishing GroupNature Communications2041-17232020-07-0111111110.1038/s41467-020-17156-xInterferon-independent STING signaling promotes resistance to HSV-1 in vivoLívia H. Yamashiro0Stephen C. Wilson1Huntly M. Morrison2Vasiliki Karalis3Jing-Yi J. Chung4Katherine J. Chen5Helen S. Bateup6Moriah L. Szpara7Angus Y. Lee8Jeffery S. Cox9Russell E. Vance10Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of CaliforniaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of CaliforniaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of CaliforniaDivision of Neurobiology, Department of Molecular and Cell Biology, University of CaliforniaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of CaliforniaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of CaliforniaDivision of Neurobiology, Department of Molecular and Cell Biology, University of CaliforniaDepartments of Biology and Biochemistry & Molecular Biology, Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State UniversityCancer Research Laboratory, University of CaliforniaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of CaliforniaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of CaliforniaSTING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.https://doi.org/10.1038/s41467-020-17156-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lívia H. Yamashiro Stephen C. Wilson Huntly M. Morrison Vasiliki Karalis Jing-Yi J. Chung Katherine J. Chen Helen S. Bateup Moriah L. Szpara Angus Y. Lee Jeffery S. Cox Russell E. Vance |
| spellingShingle |
Lívia H. Yamashiro Stephen C. Wilson Huntly M. Morrison Vasiliki Karalis Jing-Yi J. Chung Katherine J. Chen Helen S. Bateup Moriah L. Szpara Angus Y. Lee Jeffery S. Cox Russell E. Vance Interferon-independent STING signaling promotes resistance to HSV-1 in vivo Nature Communications |
| author_facet |
Lívia H. Yamashiro Stephen C. Wilson Huntly M. Morrison Vasiliki Karalis Jing-Yi J. Chung Katherine J. Chen Helen S. Bateup Moriah L. Szpara Angus Y. Lee Jeffery S. Cox Russell E. Vance |
| author_sort |
Lívia H. Yamashiro |
| title |
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo |
| title_short |
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo |
| title_full |
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo |
| title_fullStr |
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo |
| title_full_unstemmed |
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo |
| title_sort |
interferon-independent sting signaling promotes resistance to hsv-1 in vivo |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-07-01 |
| description |
STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection. |
| url |
https://doi.org/10.1038/s41467-020-17156-x |
| work_keys_str_mv |
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1721308736302088192 |