Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the glucose lowering effect of metformin.

Bibliographic Details
Main Authors: T. M. Zaved Waise, Mozhgan Rasti, Frank A. Duca, Song-Yang Zhang, Paige V. Bauer, Christopher J. Rhodes, Tony K. T. Lam
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08582-7
Description
Summary:The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the glucose lowering effect of metformin.
ISSN:2041-1723

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