Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.

Bibliographic Details
Main Authors: Xiangxi Wang, Shi-Hua Li, Ling Zhu, Qing-Gong Nian, Shuai Yuan, Qiang Gao, Zhongyu Hu, Qing Ye, Xiao-Feng Li, Dong-Yang Xie, Neil Shaw, Junzhi Wang, Thomas S. Walter, Juha T. Huiskonen, Elizabeth E. Fry, Cheng-Feng Qin, David I. Stuart, Zihe Rao
Format: Article
Language:English
Published: Nature Publishing Group 2017-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00024-6

Internet

https://doi.org/10.1038/s41467-017-00024-6

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