Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability
Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00024-6 |
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doaj-ed5e43459e464ee6a6602a849e5c6e812021-01-31T12:45:13ZengNature Publishing GroupNature Communications2041-17232017-04-01811910.1038/s41467-017-00024-6Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stabilityXiangxi Wang0Shi-Hua Li1Ling Zhu2Qing-Gong Nian3Shuai Yuan4Qiang Gao5Zhongyu Hu6Qing Ye7Xiao-Feng Li8Dong-Yang Xie9Neil Shaw10Junzhi Wang11Thomas S. Walter12Juha T. Huiskonen13Elizabeth E. Fry14Cheng-Feng Qin15David I. Stuart16Zihe Rao17National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of ScienceDepartment of Virology, Beijing Institute of Microbiology and EpidemiologyDivision of Structural Biology, University of OxfordDepartment of Virology, Beijing Institute of Microbiology and EpidemiologyNational Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of ScienceNational Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of ScienceNational Institutes for Food and Drug ControlDepartment of Virology, Beijing Institute of Microbiology and EpidemiologyDepartment of Virology, Beijing Institute of Microbiology and EpidemiologyDepartment of Virology, Beijing Institute of Microbiology and EpidemiologyNational Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of ScienceNational Institutes for Food and Drug ControlDivision of Structural Biology, University of OxfordDivision of Structural Biology, University of OxfordDivision of Structural Biology, University of OxfordDepartment of Virology, Beijing Institute of Microbiology and EpidemiologyDivision of Structural Biology, University of OxfordNational Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of ScienceJapanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.https://doi.org/10.1038/s41467-017-00024-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiangxi Wang Shi-Hua Li Ling Zhu Qing-Gong Nian Shuai Yuan Qiang Gao Zhongyu Hu Qing Ye Xiao-Feng Li Dong-Yang Xie Neil Shaw Junzhi Wang Thomas S. Walter Juha T. Huiskonen Elizabeth E. Fry Cheng-Feng Qin David I. Stuart Zihe Rao |
| spellingShingle |
Xiangxi Wang Shi-Hua Li Ling Zhu Qing-Gong Nian Shuai Yuan Qiang Gao Zhongyu Hu Qing Ye Xiao-Feng Li Dong-Yang Xie Neil Shaw Junzhi Wang Thomas S. Walter Juha T. Huiskonen Elizabeth E. Fry Cheng-Feng Qin David I. Stuart Zihe Rao Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability Nature Communications |
| author_facet |
Xiangxi Wang Shi-Hua Li Ling Zhu Qing-Gong Nian Shuai Yuan Qiang Gao Zhongyu Hu Qing Ye Xiao-Feng Li Dong-Yang Xie Neil Shaw Junzhi Wang Thomas S. Walter Juha T. Huiskonen Elizabeth E. Fry Cheng-Feng Qin David I. Stuart Zihe Rao |
| author_sort |
Xiangxi Wang |
| title |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_short |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_full |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_fullStr |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_full_unstemmed |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_sort |
near-atomic structure of japanese encephalitis virus reveals critical determinants of virulence and stability |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-04-01 |
| description |
Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence. |
| url |
https://doi.org/10.1038/s41467-017-00024-6 |
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| _version_ |
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