Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability
Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.
Bibliographic Details
| Main Authors: |
Xiangxi Wang,
Shi-Hua Li,
Ling Zhu,
Qing-Gong Nian,
Shuai Yuan,
Qiang Gao,
Zhongyu Hu,
Qing Ye,
Xiao-Feng Li,
Dong-Yang Xie,
Neil Shaw,
Junzhi Wang,
Thomas S. Walter,
Juha T. Huiskonen,
Elizabeth E. Fry,
Cheng-Feng Qin,
David I. Stuart,
Zihe Rao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-00024-6
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