Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.

Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.

Genomic instability stemming from dysregulation of cell cycle checkpoints and DNA damage response (DDR) is a common feature of many cancers. The cancer adult T cell leukemia (ATL) can occur in individuals infected with human T cell leukemia virus type 1 (HTLV-1), and ATL cells contain extensive chro...

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Bibliographic Details
Main Authors: Tajhal Dayaram, Francene J Lemoine, Lawrence A Donehower, Susan J Marriott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566092?pdf=render

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