Co-encapsulation of HNF4α overexpressing UMSCs and human primary hepatocytes ameliorates mouse acute liver failure

Co-encapsulation of HNF4α overexpressing UMSCs and human primary hepatocytes ameliorates mouse acute liver failure

Abstract Background Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor organs. Mesenchymal stem cells (MSCs) and hepatocytes are two attractive...

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Bibliographic Details
Main Authors: Defu Kong, Huiming Xu, Mo Chen, Yeping Yu, Yongbing Qian, Tian Qin, Ying Tong, Qiang Xia, Hualian Hang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Stem Cell Research & Therapy
Subjects:
Acute liver failure
Encapsulation
MSCs
HNF4α
HB-EGF
Online Access:http://link.springer.com/article/10.1186/s13287-020-01962-7

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