Cell-to-Cell Variation in Defective Virus Expression and Effects on Host Responses during Influenza Virus Infection

Cell-to-Cell Variation in Defective Virus Expression and Effects on Host Responses during Influenza Virus Infection

Defective influenza virus particles generated during viral replication carry incomplete viral genomes and can interfere with the replication of competent viruses. These defective genomes are thought to modulate the disease severity and pathogenicity of an influenza virus infection. Different defecti...

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Bibliographic Details
Main Authors: Chang Wang, Christian V. Forst, Tsui-wen Chou, Adam Geber, Minghui Wang, Wissam Hamou, Melissa Smith, Robert Sebra, Bin Zhang, Bin Zhou, Elodie Ghedin
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
influenza a virus
defective viral genome
host immune response
single-cell rna-seq
viral transcription
Online Access:https://doi.org/10.1128/mBio.02880-19

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