Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function

Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function

Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-α; however, the detailed understanding...

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Main Authors: Anisha A. Gupte, Henry J. Pownall, Dale J. Hamilton
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2015/916585
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spelling doaj-ed395869b8ea4d6f99b583a8fd4355eb2020-11-24T23:49:20ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/916585916585Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial FunctionAnisha A. Gupte0Henry J. Pownall1Dale J. Hamilton2Bioenergetics Laboratory, Houston Methodist Research Institute, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USAAtherosclerosis & Lipoprotein Research, Methodist DeBakey Heart and Vascular Institute, Houston Methodist Research Institute, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USABioenergetics Laboratory, Houston Methodist Research Institute, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USAClinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-α; however, the detailed understanding of its mechanisms is incomplete. Recent investigations suggest that estrogen receptor-α elicits the metabolic effects of estrogen by genomic, nongenomic, and mitochondrial mechanisms that regulate insulin signaling, substrate oxidation, and energetics. This paper reviews clinical and experimental studies on the mechanisms of estrogen and the current state of knowledge regarding physiological and pathobiological influences of estrogen on metabolism.http://dx.doi.org/10.1155/2015/916585
collection DOAJ
language English
format Article
sources DOAJ
author Anisha A. Gupte
Henry J. Pownall
Dale J. Hamilton
spellingShingle Anisha A. Gupte
Henry J. Pownall
Dale J. Hamilton
Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
Journal of Diabetes Research
author_facet Anisha A. Gupte
Henry J. Pownall
Dale J. Hamilton
author_sort Anisha A. Gupte
title Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
title_short Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
title_full Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
title_fullStr Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
title_full_unstemmed Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
title_sort estrogen: an emerging regulator of insulin action and mitochondrial function
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2015-01-01
description Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-α; however, the detailed understanding of its mechanisms is incomplete. Recent investigations suggest that estrogen receptor-α elicits the metabolic effects of estrogen by genomic, nongenomic, and mitochondrial mechanisms that regulate insulin signaling, substrate oxidation, and energetics. This paper reviews clinical and experimental studies on the mechanisms of estrogen and the current state of knowledge regarding physiological and pathobiological influences of estrogen on metabolism.
url http://dx.doi.org/10.1155/2015/916585
work_keys_str_mv AT anishaagupte estrogenanemergingregulatorofinsulinactionandmitochondrialfunction
AT henryjpownall estrogenanemergingregulatorofinsulinactionandmitochondrialfunction
AT dalejhamilton estrogenanemergingregulatorofinsulinactionandmitochondrialfunction
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