Synthesis and Biological Screening of 4-Benzyl-2H-phthalazine Derivatives

Synthesis and Biological Screening of 4-Benzyl-2H-phthalazine Derivatives

Preparation of 4-benzyl-2-substituted phthalazin-1-one derivatives 2-8 is reported. Condensation of 4-benzyl-1-chlorophthalazine (9) with a series of different nucleophiles gave 4-benzylphthalazin-1-ylamino derivatives (10-13 and 16) and 4-amino-2-[N'-(4-benzylphthalazin-1-yl)-hydrazino]-6-aryl...

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Bibliographic Details
Main Authors: Ahmed H. Bedair, Ahmed M. El-Agrody, Mohammed A. El-Nassag, Ashraf H.F. Abd El-Wahab, Hany M. Mohamed
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Pharmaceuticals
Subjects:
phthalazine derivatives
anthracene derivatives
synthesis
antimicrobial activity
Online Access:http://www.mdpi.com/1424-8247/4/8/1158/

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