A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.

A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.

Spatial arrangement of neurite branching is instructed by both attractive and repulsive cues. Here we show that in C. elegans, the Wnt family of secreted glycoproteins specify neurite branching sites in the PLM mechanosensory neurons. Wnts function through MIG-1/Frizzled and the planar cell polarity...

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Bibliographic Details
Main Authors: Chun-Hao Chen, Chun-Wei He, Chien-Po Liao, Chun-Liang Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5398721?pdf=render

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