Emerging concepts for PI3K/mTOR inhibition as a potential treatment for osteosarcoma [version 1; referees: 2 approved]

Emerging concepts for PI3K/mTOR inhibition as a potential treatment for osteosarcoma [version 1; referees: 2 approved]

Patients with metastatic and recurrent osteosarcoma fare poorly, and new therapeutic strategies are needed to improve survival. Several recent complementary genomic and pathway analyses of both murine and human osteosarcoma have revealed common aberrations of the phosphoinositide 3-kinase (PI3K)/mam...

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Bibliographic Details
Main Authors: Michael W. Bishop, Katherine A. Janeway
Format: Article
Language:English
Published: F1000 Research Ltd 2016-07-01
Series:F1000Research
Subjects:
Cancer Therapeutics
Cell Growth & Division
Cell Signaling
Medical Genetics
Pediatric Oncology
Sarcomas
Online Access:http://f1000research.com/articles/5-1590/v1

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