18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways

18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways

In this study we investigate the molecular mechanisms of caspases and mitochondria in the extrinsic and intrinsic signal apoptosis pathways in human leukemia HL-60 cells after in vitro exposure to 18α-glycyrrhetinic acid (18α-GA). Cells were exposed to 18α-GA at various concentrations for various ti...

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Bibliographic Details
Main Authors: Yi-Chang Huang, Chao-Lin Kuo, Kung-Wen Lu, Jen-Jyh Lin, Jiun-Long Yang, Rick Sai-Chuen Wu, Ping-Ping Wu, Jing-Gung Chung
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
18α-glycyrrhetinic acid
mitochondria
caspase-3
apoptosis
HL-60 cells
Online Access:http://www.mdpi.com/1420-3049/21/7/872

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