Effect of ulinastatin combined with atomolam therapy on myocardial inflammatory injury and oxidative damage in patients with septic shock
Objective: To analyze the effect of ulinastatin combined with atomolam therapy on myocardial inflammatory injury and oxidative damage in patients with septic shock. Methods: A total of 60 patients with septic shock were randomly divided into standard dose group (ulinastatin 200 000 U/day), high d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-12-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201624/6.pdf |
| Summary: | Objective: To analyze the effect of ulinastatin combined with atomolam therapy on myocardial
inflammatory injury and oxidative damage in patients with septic shock. Methods: A total
of 60 patients with septic shock were randomly divided into standard dose group (ulinastatin
200 000 U/day), high dose group (ulinastatin 400 000 U/day) and combined treatment group
(atomolam 1.8 g + ulinastatin 200 000 U/day), 20 cases in each group. Differences in serum
content of myocardial injury markers, inflammatory factors and oxidative damage indexes,
levels of cardiac ultrasound parameters, etc were compared between the two groups after
treatment. Results: Myocardial injury markers H-FABP, cTNⅠ, MYO, CK-MB and NTproBNP
content in serum of combined treatment group were lower than those of high dose
group and conventional dose group; inflammatory factors IL-6, IL-1β, TNF-α, PCT, MIP-2
and MCP-1 content in serum were lower than those of high dose group and conventional dose
group; oxidative damage indexes MDA, AOPP and CAT content in serum were lower than
those of high dose group and conventional dose group while SOD, T-AOC and NO content
were higher than those of high dose group and conventional dose group; ultrasound parameters
LVEDV, GEDI, SV, SVI, CO and CI levels were higher than those of high dose group and
conventional dose group. Conclusions: Ulinastatin combined with atomolam therapy is helpful
to protect the cardiac function of patients with septic shock, and has unique advantages in
inhibiting systemic inflammation and oxidative stress. |
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| ISSN: | 1007-1237 1007-1237 |