Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes

Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes

Sirt1 (Sirtuin 1), AMPK (AMP-activated protein kinase), and eNOS (endothelial nitric oxide synthase) modulate hepatic energy metabolism and inflammation and play a major role in the development of NASH. Cyclic nucleotide phosphodiesterases (PDEs) play an important role in signal transduction by modu...

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Bibliographic Details
Main Authors: Jheelam Banerjee, Antje Bruckbauer, Teresa Thorpe, Michael B. Zemel
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
AMPK
Sirt1
PDE2
PDE3
PDE5
leucine
sildenafil
NASH
obesity
Online Access:https://www.mdpi.com/1422-0067/20/12/2992

Internet

https://www.mdpi.com/1422-0067/20/12/2992

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